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> Bio chemical systems on chipBio chemical systems on chip
Contact: Raymond Campagnolo (raymond.campagnolo@cea.fr)
Developing the potential of bio systems on a chip
Bio systems on a chip (BIOSOC) have multiple applications that can provide the healthcare industry instant results at point-of-care. Biologists will be able to immediately detect air- and water-borne pathogens or infectious diseases in minute blood samples
Key capabilities of these self-contained, portable BIOSOC labs include:
- Collection
- Extraction
- Concentration
- Purification
- Detection
- On-site analysis
- Data transmission
We’ve set our sights on laying the ground work for developing self-contained portable labs that can concentrate a sample of blood, water or air, purify it, identify its molecular structure, detect pathogens, and biological toxins, and immediately transmit results to appropriate agencies.
This enables faster analysis, significant cost efficiencies and perhaps public safety by combining all these functions into a single piece of equipment. In 2008, we focused especially on the sample-preparation capability, notably around whole blood.
Next steps
The challenge is to integrate the components and functions in a “shrinking lab,” ranging in size of an MP3 player to a shoebox. This would present substantial opportunities for industrial partners to develop new tools with strong IP for a variety of applications, including:
- Medical diagnosis
- Environmental and safety monitoring
- New tools for research and production
Pushing the limits of microsystems
- Leti and four partners formed INTEGREAU to develop micro-analytical systems for continuous, on-site and real-time monitoring for heavy metals in river water. Its mission is to develop a micro-concentrator for heavy metals based on a liquid-liquid extraction concept at the microfluidic level.
- Leti developed a Smart Drop microsystem that enables us to conduct a complete biological protocol analysis with just a droplet of blood (less than 1 µl). The droplets (volume from 64nl to 1µl) are moved over a network of electrodes by the electrostatic forces created by the electrodes (EWOD: ElectroWetting On Dielectric principle).
- Leti’s biotechnologies facilities include a 150-m² clean room dedicated to the microfabrication and characterization of biochips (spotting, electrochemistry, in-situ syntheses, optical characterization and chemical engineering).
- Leti also has at its disposal, 1,000 square meters of laboratories that support advanced work in biology, chemistry, electrochemistry, microfluidics and packaging.
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