Leti, innovation
for industry
Contact: Olivier Peyret (olivier.peyret@cea.fr)
The growing global population, particularly the over-60 cohort, will combine with demands for better healthcare in developing countries to fuel significant growth in the health market.
Leti and the semiconductor industry have the opportunity to provide new concepts and breakthrough applications for advanced personalized medicine and better diagnostics that will help meet these demands, and improve the lives of many people.
We are pursuing several axes of R&D in the biological and healthcare industries:
Miniaturization, connectivity and integration are opening new pathways to decentralized diagnostics. Point-of-care has tremendous potential in developing countries where centralized diagnostic facilities are in large towns and the healthcare infrastructure remains insufficient to serve large, rural populations.
Molecular diagnostics has recently created new prospects. The search for molecular causes of diseases and its extension to diagnostics are now considered the pathway to personalized medicine. This field is still in its early days and new generations of in vitro diagnostic systems, including innovative sample-preparation techniques, are needed.
Microelectronics and microsystems are enabling technologies for implanted medical devices and will play an important role in bringing new therapies to the healthcare market. Leti’s microelectronics and microsystems enable connectivity and portability. 3D heterogeneous integration of detection layers within CMOS electronics is the key for a new generation of detectors for medical imaging and in vitro diagnostics, and we continuously add skills in materials, microfluidics and chemistry.
Lab-on-a-chip
Electrowetting-on-dielectric (EWOD) technology developed by Leti is a rare micro-fluidics platform method that allows high integration of liquid handling and complex protocol. EWOD has an enormous advantage from an integration standpoint because actuation is exclusively electric and does not require elements prone to deformation (gates or valves) or in movement (pumps, syringes).
This technology holds great promise: in 2009, Leti demonstrated lab-on-a chip processes, such as real time, polymerase chain reaction, that include sample preparation and point-of-care troponin testing.
Molecular imaging
A new system for early detection of prostate cancer combines ultrasound and fluorescence optical imaging within an endorectal probe. The ultrasound provides morphological information about the prostate, while the optical system detects and locates fluorophore-marked tumors.
In 2009, Leti focused on developing a transrectal probe adapted to fluorescence diffuse optical tomography measurements. Localization of fluorescence tracers is based on a pulsed laser and a time-resolved detection system. A reconstruction algorithm is then used to help locate and quantify fluorescence up to a clinically relevant depth of 2cm.
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